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KMID : 1103720160740010026
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Journal of the Korean Society of Radiology
2016 Volume.74 No. 1 p.26 ~ p.36
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Infusion Sclerotherapy of Microcystic Lymphatic Malformation: Clinico-Radiological Mid-Term Results
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Lee Jong-Min
Lee Seok-Jong
Chung Ho-Yun
Huh Seung
Kim Hyung-Kee
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Abstract
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Purpose
A new sclerotherapy technique by slow mechanical infusion of sclerosant was validated for treatment of microcystic lymphatic malformation (mLM).
Materials and Methods
Seventeen consecutive patients with mLM in extremities, cervicofacial area, and trunk were included (21.8 ± 21.5 years old, male:female = 5:12). All patients diagnosed as mLM were included. A total 4-32 mL 20-38% OK-432 solution was mechanically infused at the rate of 10 mL/hour into the mLM lesions. The treatment effect was estimated clinic-radiologically at the 4-month follow-up. Repeated sclerotherapy followed in the 6th month, if required. The therapeutic effect was evaluated using quantitative ultrasonographic examination including soft tissue thickness, cyst size and number.
Results
In 17 patients, total 31 infusion sclerotherapy sessions were performed and monitored for 425 ± 266 days. Fifteen patients (88%) showed improvement in all symptoms, signs, and ultrasonographic findings. In all cases, at least one finding presented improvement. The maximal number of cysts per ultrasonographic window and maximal diameter of the largest cyst decreased by 57 ± 57% and 51 ± 67%, respectively (p = 0.102, 0.004). The soft tissue thickness decreased by 18 ± 15% (p < 0.01). No significant complications such as distal lymphedema or skin necrosis occurred.
Conclusion
Infusion sclerotherapy is a safe and effective treatment technique for microcystic LM, with improved outcome.
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KEYWORD
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Lymphatic Abnormalities, Sclerotherapy, Infusions, Intralesional, Ultrasonography
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